In the cell cycle, genomic information must be precisely transmitted into two daughter cells. In response to extra- and intra-cellular information, cells initiate cell cycle and trigger various events in a correct order. Various cell cycle-related proteins are regulated so that they are present and functional in a specific phase of cell cycle (see picture). Our research involves the study of such regulation, focusing on understanding how mechanisms mediate DNA duplication and how maintenance of genomic information is controlled, because failure of such controls would result in diseases including cancer.