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研究成果
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単行本、総説(2001年以降)
日下部岳広、酒井則良、新屋みのり、服部淳彦、田畑純、鈴木信雄、吉崎範夫著・鈴木範男監修:『身近な動物を使った実験1 ホヤ メダカ・ゼブラフィッシュ キンギョ カエル』
三共出版(印刷中)
Horie, T., Sasakura, Y., Nakagawa, M., and Kusakabe, T. and Tsuda, M.: Photoreceptive systems in the ascidian nervous system. Dev. Growth Differ. 49 (3), in press (2009)
Kusakabe, T. and Tsuda, M.: Photoreceptive systems in ascidians. Photochem. Photobiol. 83 (2), 248-252 (2007)
Takimoto, N., Kusakabe, T., and Tsuda, M.: Origin of the vertebrate visual cycle. Photochem Photobiol. 83 (2), 242-247 (2007)
日下部岳広、堀江健生、川上功、大月恒、津田基之:ホヤ脳神経系の分子行動遺伝学−感覚受容から運動制御まで−
月刊海洋 号外 41, 52-60(2005)
日下部岳広:ホヤにおける遺伝子発現制御と遺伝子進化に関する研究
生物科学ニュース 405(2005年9月号), 25-31(2005)
Takehiro Kusakabe: Regulation and evolution of genes in
ascidians Zool. Sci. 22 (12), 1372 (2005)
Takehiro Kusakabe: Decoding cis-regulatory systems in
ascidians Zool. Sci. 22 (2), 129-146 (2005)
日下部岳広、津田基之:ホヤの光受容システム 生化学、第76巻
第4号, 368-373(2004)
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原著論文(2001年以降)
Itoh, H, Fujita, F., and Hatta, K. A sleep disorder in zebrafish: analysis of a population that spawn before dawn. (in Japanese with English abstract and figure legends) Reports of Graduate School of Material Science and Life Science, University of Hyogo 19, 19-28 (2008)
Yagi, H., Nakagawa, M., Takahashi, N., Kondo, S., Matsubara, M., and Kato, K. Neural complex-specific expression of xylosyl N-glycan in Ciona intestinalis. Glycobiology 18 (2), 145-151 (2008)
Shimada, A., Yabusaki, M., Niwa, H., Yokoi, H., Hatta, K., Kobayashi, D., and Takeda, H. Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm. Development 135 (2), 281-290 (2008)
Horie, T., Kusakabe, T., and Tsuda, M. Glutamatergic networks in the Ciona intestinalis larva. J. Comp. Neurol. 508 (2), 249-263 (2008)
Horie, T., Sakurai, D., Ohtsuki, H., Terakita, A., Shichida, Y., Usukura, J., Kusakabe, T., and Tsuda, M. Pigmented and nonpigmented ocelli in the brain vesicle of the ascidian larva. J. Comp. Neurol. 509 (1), 88-102 (2008)
Vandenbon, A., Miyamoto, Y., Takimoto, N., Kusakabe, T. and Nakai, K. Markov chain-based promoter structure modeling for tissue-specific expression pattern prediction. DNA Res. 15 (1), 3-11 (2008)
Sakai, T., Aoyama, M., Kusakabe, T., Tsuda, M., and Satake, H. (2008) Functions of a GnRH receptor heterodimer of the ascidian Ciona intestinalis. Acta Biol. Hung. 59 (Suppl.), 241-243.
Yoshida, R., Horie, T., Tsuda, M. and Kusakabe, T.G. Comparative genomics identifies a cis-regulatory module that activates transcription in specific subsets of neurons in Ciona intestinalis larvae. Dev. Growth Differ. 49 (8), 657-667 (2007)
Kurotaki, Y., Hatta, K., Nakao, K., Nebeshima, Y., and
Fujimori, T. Blastocyst axis is specified
independently of early cell lineage but aligns with the ZP
shape. Science 316(5825):719-723(2007)
Sierro, N., Kusakabe, T., Park, K.-J., Yamashita, R., Kinoshita,
K., and Nakai, K.
DBTGR: a database of tunicate promoters and their regulatory
elements
Nucleic Acids Res. 34, D552-D555 (2006)
Aramaki, S., and Hatta, K. Visualizing neurons
one-by-one in vivo: optical dissection and reconstruction of
neural networks with reversible fluorescent proteins. Dev.
Dyn. 235(8):2192-2199(2006)
Sayer, J.A., Otto, E.A., O'toole, J.F., Nurnberg, G., Kennedy,
M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett,
B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I.,
Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J.,
Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S.,
Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A.,
Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X.,
Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R., and
Hildebrandt, F. The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome
and activates transcription factor ATF4
Nat. Genet. 38 (6), 674-681.(2006)
Takimoto, N., Kusakabe, T., Horie, T., Miyamoto, Y., and Tsuda, M. (2006) Origin of the vertebrate visual cycle: III. Distinct distribution of RPE65 and β-carotene 15,15'-monooxygenase homologues in Ciona intestinalis. Photochem. Photobiol. 82 (6), 1468-1474.
Hatta, K., Tsujii, H., and Omura, T. Cell tracking
using a photoconvertible fluorescent protein. Nat. Prot.
1(2):960-967(2006)
Horie, T., Orii, H., and Nakagawa, M. (2005) Structure of ocellus photoreceptors in the ascidian Ciona intestinalis larva as revealed by an anti-arrestin antibody. J. Neurobiol. 65 (3), 241-250 .
Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S.,
Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M.
E-cadherin is required for gastrulation cell
movements in zebrafish. Mech. Dev. 122(6):747-763(2005)
Barran, P.E., Roeske, R.W., Pawson, A.J., Sellar, R., Bowers,
M.T., Morgan, K., Lu, Z.-L., Tsuda, M., Kusakabe, T., and Millar,
R.P.
Evolution of constrained GnRH ligand conformation and receptor
sensitivity
J. Biol. Chem. 280 (46), 38569-38575 (2005)
Otto, E.A., Loeys, B., Khanna, H., Hellemans, J., Sudbrak, R.,
Fan, S., Muerb, U., O'Toole, J.F., Helou, J., Attanasio, M., Utsch,
B., Sayer, J.A., Lillo, C., Jimeno, D., Coucke, P., De Paepe, A.,
Reinhardt, R., Klages, S., Tsuda, M., Kawakami, I., Kusakabe, T.,
Omran, H., Imm, A., Tippens, M., Raymond, P.A., Hill, J., Beales, P.,
He, S., Kispert, A., Margolis, B., Williams, D.S., Swaroop, A., and
Hildebrandt, F.
A novel ciliary IQ domain protein, NPHP5, is mutated in Senior-Loken
syndrome (nephronophthisis with retinitis pigmentosa), and interacts
with RPGR and calmodulin
Nat. Genet. 37 (3), 282-288 (2005)
Jiang, D., Tresser, J.W., Horie, T., Tsuda, M., and Smith,
W.C.
Pigmentation in the sensory organs of the ascidian larva is essential
for normal behavior
J. Exp. Biol. 208 (Pt 3), 433-438 (2005)
Kusakabe, T., Yoshida, R., Ikeda, Y., and Tsuda, M.
Computational discovery of DNA motifs associated with cell
type-specific transcription in Ciona
Dev. Biol. 276 (2), 563-580 (2004)
Sakurai, D., Goda, M., Koumura, Y., Horie, T., Iwamoto, H.,
Ohtsuki, H., and Tsuda, M.
The role of pigment cells in the brain of ascidian larva
J. Comp. Neurol. 475 (1), 70-82 (2004)
Yoshida, R., Sakurai, D., Horie, T., Kawakami, I., Tsuda, M., and
Kusakabe, T.
Identification of neuron-specific promoters in Ciona intestinalis
Genesis 39 (2), 130-140 (2004)
Ando, H., Shi, Q., Kusakabe, T., Ohya, T., Suzuki, N., and Urano,
A.
Localization of mRNAs encoding alpha and beta subunits of soluble
guanylyl cyclase in the brain of rainbow trout: comparison with the
distribution of neuronal nitric oxide synthase
Brain Res. 1013 (1), 13-29 (2004)
Ashida, A., Matsumoto, K., Ebrey, T.G., and Tsuda, M.
A purified agonist-activated G-protein coupled receptor: truncated
octopus acid metarhodopsin
Zool. Sci. 21 (3), 245-250 (2004)
Kusakabe, T., Mishima, S., Shimada, I., Kitajima, Y., and Tsuda,
M.
Structure, expression, and cluster organization of genes encoding
gonadotropin-releasing hormone receptors found in the neural complex
of the ascidian Ciona intestinalis
Gene 322, 77-84 (2003)
Tsuda, M., Kusakabe, T., Iwamoto, H., Horie, T., Nakashima, Y.,
Nakagawa, M., and Okunou, K.
Origin of the vertebrate visual cycle. II. Visual cycle proteins are
localized in whole brain including photoreceptor cells of a primitive
chordate
Vision Res. 43 (28), 3045-3053 (2003)
Inada, K., Horie, T., Kusakabe, T., and Tsuda, M.
Targeted knockdown of an opsin gene inhibits the swimming behaviour
photoresponse of ascidian larvae
Neurosci. Lett. 347 (3), 167-170 (2003)
Nakashima, Y., Kusakabe, T., Kusakabe, R., Terakita, A., Shichida,
Y., and Tsuda, M.
Origin of the vertebrate visual cycle: genes encoding retinal
photoisomerase and two putative visual cycle proteins are expressed
in whole brain of a primitive chordate
J. Comp. Neurol. 460 (2), 180-190 (2003)
Tsuda, M., Sakurai, D., and Goda, M.
Direct evidence for the role of pigment cells in the brain of
ascidian larvae by laser ablation
J. Exp. Biol.,206(8), 1409-1417 (2003)
Tsuda, M., Kawakami, I., and Shiraishi, S.
Sensitization and habituation of the swimming behavior in ascidian
larvae to light
Zool. Sci. 20, 13-22 (2003)
Iwasa, T., Mishima, S., Watari, A., Ohkuma, M., Azuma, T.,
Kanehara, K., and Tsuda. M.
A novel G protein alpha-subunit in embryo of the ascidian,
Halocynthia roretzi
Zool. Sci. 20, 141-152 (2003)
Yoshida, R., Kusakabe, T., Kamatani, M., Daitoh, M., and Tsuda,
M.
Central nervous system-specific expression of G protein alpha-subunit
isoforms in the ascidian Ciona intestinalis
Zool. Sci. 19 (10), 1079-1088 (2002)
Nakagawa, M., Orii, H., Yoshida, N., Jojima, E., Horie, T.,
Yoshida, R., Haga , T., and Tsuda, M.
Ascidian arrestin (Ci-arr), the origin of the visual and nonvisual
arrestins of vertebrate
Eur. J. Biochem. 269 (21), 5112-5118 (2002)
Kusakabe, T., Nakashima, Y., Kusakabe, R., Takeo, H., Kawakami,
I., Yoshida, R., Inada, K., Nakagawa, M., and Tsuda, M.
Phototransduction and visual cycle in the ascidian tadpole larva
J. Photosci. 9 (2), 37-40 (2002)
Horie,T., Nakagawa, M., Orii, H., and Tsuda, M.
Whole structure of the photoreceptors in the ascidian larva
visualized by an antibody against arrestin (Ci-Arr)
J. Photosci. 9 (2), 272-274 (2002)
Satou, Y., Takatori, N., Fujiwara, S., Nishikata, T., Saiga, H.,
Kusakabe, T., Shin-i, T., Kohara, Y., and Satoh, N.
Ciona intestinalis cDNA projects: EST analyses and gene expression
profiles during embryogenesis
Gene 287 (1-2), 83-96 (2002)
Nishioku, Y., Nakagawa, M., Tsuda, M., and Terazima, M.
Energetics and volume changes of the intermediates in the photolysis
of octopus rhodopsin at a physiological temperature
Biophys. J. 83 (2), 1136-1146 (2002)
Kawakami,I., Siraishi,I., and Tsuda, M.
Photoresponse and learning behavior of ascidian larvae, a primitive
chordate, to repeated stimuli of step-up and step-down of light
J. Biol. Physic. 28, 1-11(2002)
Okano, K., Oishi,T., Miyashita, Y., Moriya, T., Tsuda, M.,
Irie,T., Ueki, N., and Seki, T.
Identification of 3,4-didehydroretinal Isomers in photosensitive
melanophores of the Xenopus tadpole tail fin
Zool. Sci. 19, 191-195 (2002)
Kusakabe, T., Yoshida, R., Kawakami, I., Kusakabe, R., Mochizuki,
Y., Yamada, L., Shin-i, T., Kohara, K., Satoh, N., Tsuda, M., and
Satou, Y.
Gene expression profiles in tadpole larvae of Ciona intestinalis
Dev. Biol. 242 (2),188-203 (2002)
Kusakabe, T., Kusakabe, R., Kawakami, K., Satou, Y., Satoh, N.,
and Tsuda, M.
Ci-opsin1, a vertebrate-type opsin gene, expressed in the larval
ocellus of the ascidian Ciona intestinalis
FEBS Lett. 506 (1), 69-72 (2001)
Kuriyama, H., Nakagawa, M., and Tsuda, M.
Intracellular Ca2+ changes induced by in vitro ischemia in rat
retinal slices
Exp. Eye Res. 73 (3),365-374 (2001)
Nakagawa, M. Miyamoto,T., Kusakabe, R., Takasaki, S., Takao,T.,
Shichida ,Y., and Tsuda, M.
O-glycosylation of G-protein coupled receptor, octopus rhodopsin
FEBS Lett. 496, 19-24 (2001)
Nishioku,Y., Nakagawa, M., Tsuda, M., and Terazima,M.
A spectrally silent transformation in the photolysis of octopus
rhodopsin: a protein conformational change without any accompanying
change of the chromophore's absorption
Biophys. J. 80 (6), 2922-2927 (2001)
Kuriyama, H., Waki, M., Nakagawa, M., and Tsuda, M.
Involvement of oxygen free radicals and intracellular calcium
dynamics in experimental retinal ischemia
Ophthalmic Res. 33 (4),196-202 (2001)
Kusakabe, T. and Suzuki, N.
A cis-regulatory element essential for photoreceptor-specific
expression of a medaka retinal guanylyl cyclase gene
Dev. Genes Evol. 211 (3), 145-149 (2001)
Tsuda, M., Ohkuma, M., Nakagawa, M., and Katagiri, Y.
Light regulated GnRH neurons in biological clock for reproduction in
the ascidin, Halocynthia roretzi
The Biology of Ascidians (Springer) pp 131-136 (2001)
Iwasa, T., Kanehara, K., Watari, A., Ohkuma, M., Nakagawa, M., and
Tsuda, M.
Hererotrimc G protein alpha and beta subunit genes of the ascidian,
Halocynthia roretzi
The Biology of Ascidians (Springer) pp 147-152 (2001)
Tsuda,M., Kawakami,I., Miyamoto,T., Nakagawa,M., Shiraishi, S.,
and Gouda,M.
Photoresponse and habituation of swimming behavior of ascidian
larvae, Ciona intestinalis
The Biology of Ascidians (Springer) pp 153-157 (2001)
Kusakabe, T.
Evolution of anural development in ascidians: role of muscle-specific
differentiation genes
The Biology of Ascidians (Springer) pp 225-229 (2001)
Hatta, K., N. Ankri, D. S. Faber and H. Korn
Slow inhibitory potentials in the teleost Mauthner cells.
Neuroscience 103, 561-579.(2001)
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