| Position |
Professor |
|
| Study |
1975-1979 |
Faculty of Science, Osaka University |
|
1979-1984 |
Graduate School of Science, Osaka University |
| Ph. D. |
1984 |
Osaka University |
| Research Fellow |
1984 |
Institute for Protein Research, Osaka University |
| Research Associate |
1985 |
Basic Research Institute, Himeji Institute of Technology |
| Lecturer |
1990 |
Faculty of Science, Himeji Institute of Technology |
| Associate Professor |
1995 |
Graduate School of Science, Kyoto University |
| Professor |
2002 |
Graduate School of Science, Himeji Institute of Technology |
| Professor |
2004 |
Graduate School of Life Science, University of Hyogo |
| Dean |
2014-2016 |
Graduate School of Life Science |
| Vice President |
2020 |
University of Hyogo |
| Director / Vice President |
2021 |
Hyogo Public University Corporation / University of Hyogo |
Fields: Structural biology, Protein crystallography
Interests: Proteins in energy metabolism (Hydrogenases etc.) and in signal transduction (Axin etc.)
Hobby: Culture of Peony, Walking, Tennis
Contact :
TEL : (+81)-791-58-0179
FAX : (+81)-791-58-0177
E-mail : hig
@sci.u-hyogo.ac.jp
Awards:
The Crystallographic Society of Japan Award for 1999 (November 25, 1999) Title: X-ray Crystallographic Study on Hydrogenase
The 38th Iue Culture Award for Science and Technology (October 4, 2014) Title: X-ray Structural Studies on Proteins
The Hyogo Science Award for 2017 (November 7, 2017) Title: Structural Chemistry on Hydrogenases
The Commendation for Science and Technology by the MEXT for 2020 (Prizes for Science and Technology, Research Category, April 7, 2020) Title: Structural Basis on the Molecular Mechanism of Hydrogen Metabolism by Hydrogenases
Recent Selected Papers:
"Structural Basis of the Function of [NiFe]-hydrogenases"
K. Nishikawa, H. Ogata and Y. Higuchi
Chemistry Letters 49(2), 164-173 (2020).
"A Direct Heterotypic Interaction between the DIX Domains of Dishevelled and Axin mediates signaling to β-catenin"
K. Yamanishi, M. Fiedler, S. Terawaki, Y. Higuchi, M. Bienz and N. Shibata
Science Signalling 12, eaaw5505 (2019).
"Redox-dependent Conformational Changes of a Proximal [4Fe-4S] Cluster in Hyb-type [NiFe]-hydrogenase to Protect the Active Site from O2"
N. D. M. Noor, H. Matsuura, K. Nishikawa, H. Tai, S. Hirota, J. Kim, J. Kang, M. Tateno, K-S. Yoon, S. Ogo, S. Kubota, Y. Shomura and Y. Higuchi
Chem. Commun. 54, 12385-12388 (2018).
"Structural Basis of the Redox Switches in the NAD+-reducing Soluble [NiFe]-hydrogenase"
Y. Shomura, M. Taketa, H. Nakashima, H. Tai, H. Nakagawa, Y. Ikeda, M. Ishii, Y. Igarashi, H. Nishihara,
K-S. Yoon, S. Ogo, S. Hirota and Y. Higuchi
Science 357 (6354), 928-932 (2017).
"Structural Basis for Ccd1 Autoinhibition in the Wnt Pathway through Homomerization of the DIX Domain"
S. Terawaki, S. Fujita, T. Katsutani, K. Shiomi, K. Keino-Masu, M. Masu, K. Wakamatsu, N. Shibata and Y. Higuchi
Scientific Reports 7(1), 7739 (2017).
"Domain Swapping Oligomerization of Thermostable c-type Cytochrome in E. coli Cells"
Y. Hayashi, M. Yamanaka, S. Nagao, H. Komori, Y. Higuchi and S. Hirota
Scientific Reports 6, 19334 (2016).
"Structural Insights into the O2 Reduction Mechanism of Multicopper Oxidase"
H. Komori and Y. Higuchi
J. Biochem. (Tokyo) 158(4), 293-298 (2015).
"Catalytic Cycle of Cytochrome-c3 Hydrogenase, a [NiFe]-enzyme, Deduced from the Structures of the Enzyme and the Enzyme Mimic"
T. Yagi, S. Ogo and Y. Higuchi
Int. J. Hydrogen. Energy 39 (32), 18543-18550 (2014).
"Structural Aspects of [NiFe]-hydrogenases"
Y. Shomura and Y. Higuchi
Rev. Inorg. Chem. 33(4), 173-192(2013).
"An O-Centered Structure of the Trinuclear Copper Center in the Cys500Ser/Glu506Gln Mutant of CueO and Structural Changes in Low to High X-Ray Dose Conditions"
H. Komori, R. Sugiyama, K. Kataoka, Y. Higuchi, and T. Sakurai
Angew. Chem. Int. Ed. 51, 1861-1864 (2012): Selected as a "HOT PAPER"
"Structural and Enzymatic Characterization of BacD, An l-amino Acid Dipeptide Ligase from Bacillus subtilis "
Y. Shomura, E. Hinokuchi, H. Ikeda, A. Senoo, Y. Takahashi, J. Saito, H. Komori, N. Shibata, Y. Yonetani and Y. Higuchi
Protein Science 21, 707-716 (2012). Selected as a "Highlight Paper"
"The Three-dimensional Structure of Nylon Hydrolase and the Mechanism of Nylon-6 Hydrolysis"
S. Negoro, N. Shibata., Y. Tanaka ,K. Yasuhira, H. Shibata, H. Hashimoto, Y.-H. Lee, S. Oshima, R. Santa, S. Oshima, K. Mochiji, Y. Goto, T. Ikegami, K. Nagai, D. Kato, M. Takeo and Y. Higuchi
J. Biol. Chem. 287, 5079-5090 (2012).
"Structural Basis for a [4Fe-3S] Cluster in the Oxygen-tolerant Membrane-bound [NiFe]-hydrogenase"
Y. Shomura, K. Yoon, H. Nishihara and Y. Higuchi
Nature 479, 253-257 (2011).
"Cytochrome c polymerization by successive domain swapping at the C-terminal helix"
S. Hirota, Y. Hattori, S. Nagao, M. Taketa, H. Komori, H. Kamikubo, Z. Wang, I. Takahashi, S. Negi, Y. Sugiura, M. Kataoka and Y. Higuchi
Pro. Natl. Acad. Sci. USA 107, 12854-12859 (2010).
"[NiFe] Hydrogenases: Structural and Spectroscopic Studies of the Reaction Mechanism"
H. Ogata, W. Lubitz and Y. Higuchi
Dalton Transactions 37, 7577- 7587 (2009).
"The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization"
T. Schwarz-Romond, M. Fiedler, N. Shibata, P. Jonathan G. Butler, A. Kikuchi, Y. Higuchi and M. Bienz
Nat. Struct. Mol. Biol. 14, 484-492 (2007).
"A Dinuclear Ni(mu-H)Ru Complex Derived from H2"
S. Ogo, R. Kabe, K. Uehara, B. Kure, T. Nishimura, S. C. Menon, R. Harada, S. Fukuzumi, Y. Higuchi, T. Ohhara, T. Tamada and R. Kuroki
Science 316, 585-587 (2007).
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