Staff

Yoshiki Higuchi
Naoki Shibata
Koji Nishikawa
Midori Taketa
Kiriko Hataguchi
Yoko Ikeda
Kayoko Matsumoto
Ikumi Miyagawa
Professor
Associate Professor
Assistant Professor
Research Assistant
Technical Staff
Technical Staff
Technical Staff
Secretary



Graduate students

Hiroaki Matsuura
Takahiro Imanishi
Shota Inoue
Kaname Shimizu
Akinori Tanigaki
Tomoki Ikeda
Rin Ohama
Takafumi Chuji
Hinata Yoshimura
H5
H4
M2
M2
M2
M1
M1
M1
M1









Yoshiki Higuchi (born 1956)



Position Professor
Study 1975-1979 Faculty of Science, Osaka University
1979-1984 Graduate School of Science, Osaka University
Ph. D. 1984 Osaka University
Research Fellow 1984 Institute for Protein Research, Osaka University
Research Associate 1985 Basic Research Institute, Himeji Institute of Technology
Lecturer 1990 Faculty of Science, Himeji Institute of Technology
Associate Professor 1995 Graduate School of Science, Kyoto University
Professor 2002 Graduate School of Science, Himeji Institute of Technology
Professor 2004 Graduate School of Life Science, University of Hyogo

Fields: Structural biology, Protein crystallography
Interests: Proteins in energy metabolism (Hydrogenases etc.) and in signal transduction (Axin etc.)
Hobby: Culture of Peony, Walking, Tennis

Contact :
TEL : (+81)-791-58-0179
FAX : (+81)-791-58-0177
E-mail : hig
@sci.u-hyogo.ac.jp


Awards:
The Crystallographic Society of Japan Award for 1999 (November 25, 1999) Title: X-ray Crystallographic Study on Hydrogenase
The 38th Iue Culture Award for Science and Technology (October 4, 2014) Title: X-ray Structural Studies on Proteins

Recent Selected Papers:
"Structural Aspects of [NiFe]-hydrogenases"
Y. Shomura and Y. Higuchi 
Rev. Inorg. Chem. 33(4), 173-192(2013).

"An O-Centered Structure of the Trinuclear Copper Center in the Cys500Ser/Glu506Gln Mutant of CueO and Structural Changes in Low to High X-Ray Dose Conditions"
H. Komori, R. Sugiyama, K. Kataoka, Y. Higuchi, and T. Sakurai 
Angew. Chem. Int. Ed. 51, 1861-1864 (2012): Selected as a "HOT PAPER"

"Structural and Enzymatic Characterization of BacD, An l-amino Acid Dipeptide Ligase from Bacillus subtilis "
Y. Shomura, E. Hinokuchi, H. Ikeda, A. Senoo, Y. Takahashi, J. Saito, H. Komori, N. Shibata, Y. Yonetani and Y. Higuchi 
Protein Science 21, 707-716 (2012). Selected as a "Highlight Paper"

"The Three-dimensional Structure of Nylon Hydrolase and the Mechanism of Nylon-6 Hydrolysis"
S. Negoro, N. Shibata., Y. Tanaka ,K. Yasuhira, H. Shibata, H. Hashimoto, Y.-H. Lee, S. Oshima, R. Santa, S. Oshima, K. Mochiji, Y. Goto, T. Ikegami, K. Nagai, D. Kato, M. Takeo and Y. Higuchi 
J. Biol. Chem. 287, 5079-5090 (2012).

"Structural Basis for a [4Fe-3S] Cluster in the Oxygen-tolerant Membrane-bound [NiFe]-hydrogenase"
Y. Shomura, K. Yoon, H. Nishihara and Y. Higuchi 
Nature 479, 253-257 (2011).

"Cytochrome c polymerization by successive domain swapping at the C-terminal helix"
S. Hirota, Y. Hattori, S. Nagao, M. Taketa, H. Komori, H. Kamikubo, Z. Wang, I. Takahashi, S. Negi, Y. Sugiura, M. Kataoka and Y. Higuchi 
Pro. Natl. Acad. Sci. USA 107, 12854-12859 (2010).

"[NiFe] Hydrogenases: Structural and Spectroscopic Studies of the Reaction Mechanism"
H. Ogata, W. Lubitz and Y. Higuchi 
Dalton Transactions 37, 7577- 7587 (2009).

"The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization"
T. Schwarz-Romond, M. Fiedler, N. Shibata, P. Jonathan G. Butler, A. Kikuchi, Y. Higuchi and M. Bienz
Nat. Struct. Mol. Biol. 14, 484-492 (2007).

"A Dinuclear Ni(mu-H)Ru Complex Derived from H2"
S. Ogo, R. Kabe, K. Uehara, B. Kure, T. Nishimura, S. C. Menon, R. Harada, S. Fukuzumi, Y. Higuchi, T. Ohhara, T. Tamada and R. Kuroki
Science 316, 585-587 (2007).




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M. Okamoto and Y.Higuchi
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